PROSPERO International prospective register of systematic reviews. Available from: Ĭomprehensive Meta-analysis. Systematic reviews: Synthesis of best evidence for clinical decisions. Churchill Livingstone: 2000.Ĭook DJ, Mulrow CD, Haynes RB. Evidence-Based Medicine: How to practice and teach EBM. Sackett D, Strauss S, Richardson W, et al. It can also help to serve as a beginner’s guide for both users and producers of systematic reviews and to appreciate some of the methodological issues. This article highlights the key features of systematic reviews, and is designed to help readers understand and interpret them.
Systematic reviews of literature can be undertaken for all types of questions, and all types of study designs. The graphical output of meta-analysis is a forest plot which provides information on individual studies and the pooled effect.
Meta-analysis is a statistical tool that provides pooled estimates of effect from the data extracted from individual studies in the systematic review. These key features can be remembered as six ‘A’ Ask, Access, Assimilate, Appraise, Analyze and Apply. The key components of a systematic review are a well-defined research question, comprehensive literature search to identify all studies that potentially address the question, systematic assembly of the studies that answer the question, critical appraisal of the methodological quality of the included studies, data extraction and analysis (with and without statistics), and considerations towards applicability of the evidence generated in a systematic review. Systematic reviews involve the application of scientific methods to reduce bias in review of literature.
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